Rock Band 4'ün DLC'siz sahip olacağı şarkı sayısı Guitar Hero: Live'dan az olsa da oyunun DLClerle birlikte yaklaşık 1500 şarkıya destek vereceğini belirtelim. Oyunun tüm şarkı listesi arasında Arctic Monkeys, Aerosmith, Avenged Sevenfold, Judas Priest, REM ve Dream Theater gibi başarılı grupların olması türü seven oyuncuların ilgisini çekecektir. Oyunun çıkışında sahip olacağı tüm şarkılar şunlar:
.38 Special - "Caught Up In You"
4 Non Blondes - "What's Up?"
Aerosmith - "Toys in the Attic"
Arctic Monkeys "Arabella"
Avenged Sevenfold - "Hail to the King"
Benjamin Booker - "Violent Shiver"
Brad Paisley ft. Keith Urban - "Start a Band"
Brandi Carlile - "Mainstream Kid"
Cake - "Short Skirt/Long Jacket"Dark Wheels - "V-Bomb"
Disturbed - "Prayer"
Dream Theater - "Metropolis - Part 1 - 'The Miracle And The Sleeper'"Duck & Cover - "Knock 'Em Down"
Eddie Japan - "Albert"
Elvis Presley - "Suspicious Minds"
Fall Out Boy- "Centuries"
Fleetwood Mac - "You Make Loving Fun"
Foo Fighters - "The Feast and the Famine"Gary Clark Jr. - "Ain't Messin' Around"
Gin Blossoms - "Follow You Down"
Grouplove - "Tongue Tied"
Halestorm - "I Miss The Misery"
Heart - "Kick It Out"
Heaven's Basement - "I Am Electric"
Imagine Dragons - "I Bet My Life"
Jack White- "Lazaretto"
Jeff Allen ft. Noelle LeBlanc and Naoko Takamoto - "Recession"
Johnny Blazes and the Pretty Boys - "Cold Clear Light"
Judas Priest - "Halls Of Valhalla"Lightning Bolt - "Dream Genie"
Little Big Town - "Little White Church"
Live - "All Over You"
Lucius - "Turn It Around"
Lynyrd Skynyrd - "That Smell"
Mark Ronson ft. Bruno Mars - "Uptown Funk"
Mumford & Suns - "The Wolf"
Ozzy Osbourne - "Miracle Man"Paramore - "Still Into You"
Queens of the Stone Age - "My God Is The Sun"
REM - "The One I Love"Rick Derringer - "Rock and Roll, Hoochie Koo"
Rush - "A Passage To Bangkok"
Scandal - "The Warrior"
Scorpions - "No One Like You"Slydigs - "Light The Fuse"
Soul Remnants - "Dead Black (Heart of Ice)"
Soundgarden - "Superunknown"
Spin Doctors - "Little Miss Can't Be Wrong"
St. Vincent - "Birth In Reverse"
System of a Down - "Spiders"
The Black Keys - "Fever"
The Both - "Milwaukee"
The Cure - "Friday I'm In Love"
The Killers - "Somebody Told Me"
The Mighty Mighty Bosstones - "The Impression That I Get"
The Outfield - "Your Love"
The Protomen - "Light Up The Night"
The Who - "The Seeker"
Tijuana Sweetheart - "Pistol Whipped"
Van Halen - "Panama"
Van Morrison - "Brown Eyed Girl"
The Waring - "Free Falling"
White Denim - "At Night In Dreams"