Activision tarafından yapılan açıklamaya göre, Guitar Hero 5, Guitar Hero World Tour’a göre bazı düzenleme ve eklentiler içerecek.
Oyuncuların kendi gruplarını istedikleri gibi şekillendirebilecekleri oyunda yer alacak gruplar ve sanatçılar listesi şu şekilde ;
3 Doors Down
A Perfect Circle
FI
Attack! Attack!
Band Of Horses
Beastie Boys
Beck
Billy Idol
Billy Squier
Blink-182
Blur
Bob Dylan
Bon Jovi
Brand New
Bush
Children of Bodom
Coldplay
Darker My Love
Darkest Hour
David Bowie
Deep Purple
Dire Straits
Duran Duran
Eagles Of Death Metal
Elliott Smith
Elton John
Face to Face
Garbage
Gorillaz
Gov’t Mule
Grand Funk Railroad
Iggy Pop
Iron Maiden
Jeff Beck
Jimmy Eat World
John Mellencamp
Johnny Cash
Kaiser Chiefs
King Crimson
Kings Of Leon
Kiss
Love and Rockets
Megadeth
Mötley Crüe
Muse
My Morning Jacket
Nirvana
No Doubt
Peter Frampton
Public Enemy Featuring Zakk Wylde
Queen & David Bowie
Queens Of The Stone Age
Rammstein
Rose Hill Drive
Rush
Santana
Scars On Broadway
Screaming Trees
Smashing Pumpkins
Sonic Youth
Spacehog
Stevie Wonder
Sublime
Sunny Day Real Estate
T. Rex
The Bronx
The Derek Trucks Band
The Duke Spirit
The Killers
The Police
The Raconteurs
The Rolling Stones
The Sword
The White Stripes
Thin Lizzy
Thrice
Tom Petty
Tom Petty & The Heartbreakers
TV On The Radio
Vampire Weekend
Weezer
Wild Cherry
Wolfmother